Chronic cold stress regulates ascending noradrenergic pathways

Abstract

Chronic exposure to cold in rats alters the activity of locus coeruleus (LC) neurons. In this study we aimed to examine the cellular effect of cold stress on catecholamine neurons, and determine whether this is specific to the LC compared with other catecholamine cell groups. Male SpragueDawley rats were subjected to 21 days of isolation under ambient conditions, chronic cold exposure at 5 °C, or after chronic cold followed by return to ambient temperature for 7 or 14 days. In the LC, chronic cold exposure significantly reduced tyrosine hydroxylase (TH) mRNA expression by approximately 45% compared with control rats, and remained significantly reduced (approximately 36%) after return to ambi..